A)Systemic sclerosis without Scleroderma:- i.e internal organ involvement without cutaneous scleroderma. B)Overlap syndrome:- scleroderma associated with other autoimmune disease. C)localized scleroderma:- scleroderma without internal organ involvement. Charachterized by Morphoea which are local patches of scleroderma. D)Limited scleroderma(CREST Syndrome):- There is minimal visceral involvement, positive anticentromere antibodies and good prognosis. Skin hardening is limited to face,feet and fingers. (Calcinosis,Raynaud's phenomenon,Esophageal dysfunction,Sclerodactly,Telangectasia.) E)Diffuse scleroderma:- Diffuse thickening of trunk,proximal and distal limbs with internal organ development and damage so it is life threatening.
Functional disability at the 1st year after start of disease. Radiographic evidence of erosion. Extra-articular manifestations. Subcutanous nodules. High positive Rheumatoid factor.