-Variants(Types)of Scleroderma.

Variants(Types)of Scleroderma.

"Sold"

A)Systemic sclerosis without Scleroderma:-
i.e internal organ involvement without cutaneous scleroderma.
B)Overlap syndrome:-
scleroderma associated with other autoimmune disease.
C)localized scleroderma:-
scleroderma without internal organ involvement.
Charachterized by Morphoea which are local patches of scleroderma.
D)Limited scleroderma(CREST Syndrome):-
There is minimal visceral involvement, positive anticentromere antibodies and good prognosis.
Skin hardening is limited to face,feet and fingers.
(Calcinosis,Raynaud's phenomenon,Esophageal dysfunction,Sclerodactly,Telangectasia.)
E)Diffuse scleroderma:-
Diffuse thickening of trunk,proximal and distal limbs with internal organ development and damage so it is life threatening.

Dr Ibrahim

-Treatment of urticaria.

Treatment of urticaria

"Scar"

Systemic steroids(sever cases resistant to treatment).
Soothing lotions locally.

Ca gluconate.

Adrenaline.
Antihistamines.

Removal of the cause.

Dr Ibrahim

-Protozoa causing Dermatologic lesions.

Protozoa causing Dermatologic lesions.
"late"

• Leishmania donovani(Post Kala azar dermal leishmaniasis).
• Leishmania brasiliense(Ulcer).
• Leishmania donovani(oriental ulcer).
• Acanthamoeba castellanii (Skin granuloma)
• Trypanosoma cruzi(chagoma)
• Trypanosoma brucei gambiense,rhodesiense(Chancre).
• Entamoeba histolytica(Cutaneous ulcer in the right hypochondrium and perianal area.)

Dr Ibrahim

- Nematodes affecting skin and s.c tissue.

Nematodes affecting skin and subcutaenous tissue.

"Hook was old"

Hook worms(Ground itching).


Wuchereria Bancrofti,Wuchereria malayi(they cause Elephentiasis).
Ancylstoma caninum,Ancylstoma Brazilliense (they cause creeping eruption).
Strongyloides stercoralis (creeping eruption).




Onchocerca volvulus(Nodules and Elephentiasis).
Loa Loa (Calabar swelling).
Dracunculus medinensis(ulcer and cellulitis).

Dr Ibrahim

- Human Skin Histology.

-Human skin is considered the largest organ of the body and form  about 16% of the body weight (1) with a surface area somewhat less than 1.5 m² (2).
-The skin form the external surface of the human body.At the orifices of the mouth,nose and the anal canal, the skin join the mucous membrane at the muco-cutaneous junction (3).

-Types of human skin (1):-

1. Thick skin (Non-Hairy) which has thick epidermis and found only in the palms and soles as they are the most sites subjected to abrasions and trauma and thick skin shows characteristic parallel ridges and grooves which are called "Finger prints".
2. Thin skin (Hairy) which has thin epidermis and covers the rest of the body.
   

-Histological structure of the skin :-

skin is composed of 3 layers

1. Epidermis
2. Dermis
3. Hypodermis (Subcutaneous fatty layer) 

1- Epidermis:-

• It is the outer superficial epithelial layer of skin.
• It is composed of Stratified squamous keratinized epithelium.
• The thickness of the epidermis varies in different types of skin. It is the thinnest on the eyelids and the thickest on the palms(0.8mm) and soles(1.4mm).
• The epidermis is ectodermal in origin.
  
• The epidermis is devoid of blood vessels and gets its nutrition through diffusion.