Saturday, April 17, 2010

- Felty's syndrome.

Felty's syndrome
*DeF:- It is a disorder characterized by the combination of rheumatoid arthritis, splenomegaly,neutropenia and repeated infections.
*It occurs in 5% of adult.
*Clinical picture:-
  • Skin pigmentation and generalized lymphadenopathy.
  • Splenomegaly.
  • Hepatomegaly.
  • Highly erosive and deforming arthiritis.
  • L.E cells are +ve.
  • Neutropenia so increase liability to certain infections.
  • Fever, weight loss, and/or fatigue.
  • Recurrent serous Infections.
  • Hypersplenism causing anaemia and thrombocytopenia.
  • Lymphadenopathy.
  • Skin hyperpigmentation and cutaneous ulceration.
  • A complete blood count ( CBC) may show Neutropenia.
  • Biochemical investigations of Rheumatoid arthritis(RF,ANA,LE).
  • An abdominal ultrasound may confirm a swollen spleen.
  • The best treatment for Felty's syndrome is to control the underlying RA, Immunosuppressive therapy for RA often improves granulocytopenia and splenomegaly.
  • Treatment of infections.
  • Splenectomy(removal of the spleen)may improve neutropenia in severe cases.
    Dr Ibrahim
    Return to list of medical syndromes here

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