Wednesday, March 24, 2010

-Lambert-Eaton syndrome.


Lambert-Eaton syndrome
or
Myasthenic-myopayhic syndrome.

*Pathophysiology:-

  • a myasthenic syndrome due to autoimmune orocess targeting the mechanism of releasing A.CH from nerve terminals.
  • It often associated with bronchogenic carcinoma or other malignancies.
*Clinical picture:-
Proximal weakness,wasting and fatigue but with less common ocular and bulbar affection than Myasthenia.

*Diagnosis:-

  • EMG:- shows paradoxical increase  in successive muscle contractions.
  • No significant response to prostigmine,but respond to guanidine HCL 20 mg/Kg/day or prednisolone+imuran.
  • No acetylecholine receptor antibodies.
  • CXR to determine if associated with bronchogenic carcinoma or not.
*Treatment:-
  • Treatment of the underlying neoplasm.
  • Plasmapheresis.
  • Immunosuppression.

Dr Ibrahim

Return to list of medical syndromes here

1 comment:

  1. Very well written and informative article, thank you :-)

    TOSHIBA PLT-805AT

    ReplyDelete

Nice to see your comment here........