Wednesday, March 24, 2010

-Lambert-Eaton syndrome.

Lambert-Eaton syndrome
Myasthenic-myopayhic syndrome.


  • a myasthenic syndrome due to autoimmune orocess targeting the mechanism of releasing A.CH from nerve terminals.
  • It often associated with bronchogenic carcinoma or other malignancies.
*Clinical picture:-
Proximal weakness,wasting and fatigue but with less common ocular and bulbar affection than Myasthenia.


  • EMG:- shows paradoxical increase  in successive muscle contractions.
  • No significant response to prostigmine,but respond to guanidine HCL 20 mg/Kg/day or prednisolone+imuran.
  • No acetylecholine receptor antibodies.
  • CXR to determine if associated with bronchogenic carcinoma or not.
  • Treatment of the underlying neoplasm.
  • Plasmapheresis.
  • Immunosuppression.

Dr Ibrahim

Return to list of medical syndromes here

1 comment:

  1. Very well written and informative article, thank you :-)



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