Plummer-Vinson Syndrome
- Synonyms:-
Chronic Pharyngo-oesophagitis or Patterson-Brown-Kelly's disease.
-Definition:-
Chronic inflammation of the mucous membrane of the hypopharynx and upper oesophagus.
-Aetiology:-
Unknown, may be iron deficiency anaemia, vitamin deficiency or autoimmune.
- Incidence:-
Commonly in females above 40 years.
-Pathology:-
Atrophic mucosa and submucosal fibrosis leading to formation of webs.
-Clinical picture:-
Symptoms: gradual progressive dysphagia.
Signs:-
- Angular stomatitis with fissured angles of the mouth
- glossitis: (smooth glazed dry tongue)
- glazed atrophic mucosa of the hypopharynx and upper oesophagus with mucosal webs
- splenomegaly
- spooning of the nails (Koilonychia).
-Investigations:-
• Blood picture shows hypochromic microcytic anaemia.
• Gastric secretions: achlorohydria due to atrophic gastritis may be caused by vit. B12 deficiency.
• Hypopharyngoscopy: web formation and stenosis.
- Complications:-
• Submucosal fibrosis leading to web formation and stenosis.
• Pre-cancerous leads to Post-cricoid carcinoma.
-Treatment:-
• Iron and vitamin B complex by injection.
• Repeated endoscopic dilatation.
• Regular follow up to detect early post-cricoid carcinoma.
No comments:
Post a Comment
Nice to see your comment here........