-Congenital Rubella Syndrome.

Congenital Rubella Syndrome

Aetiology:-
Maternal infection by rubella leads to Maternal viremia which lead to transplacental spread of the virus to the fetus causing fetal viremia whcih in turn leads to infection invloving many fetal organs and hence congenital anomalies.

N.B:- Newborn discharge virus in his secretions for 12-18 months after birth so he is infectious.
Incidence:-
*In the 1st trimester:- 15-20%.
*In the 4th month:- 5%.   

-Factors affecting human linear growth.

Factors affecting human linear growth.

• Age
• Sex
• Race.
• Hereditary factors:- Children of two short parents will probably be short and vice versa.
• Endocrinal factors e.g Growth Hormone which is responsible for stimulation of body growth in humans.
• Nutritional factors:- Adequate nutrients must be available for normal growth.
• General health:- Any serious systemic disease in childhood is likely to reduce growth (e.g. chronic kidney disease or chronic infection).
• Intrauterine growth retardation (small birth weight):-These infants often growpoorly in the long term.
• Emotional deprivation and psychological factors:- These can impair growth by complex, poorly understood mechanisms.
• Chromosomal abnormalities.
• Skeletal maturity.

Dr Ibrahim

- Protozoa with blind end in man.

Protozoa with blind end in man
"ANTS"

Acanthamoeba castellanii(brain cyst).
Naegleria fowleri (brain cyst).
Toxoplasma gondii (cysts in male patient).
Sarcocystis lindemanni ( mascular sarcocystosis).

Dr Ibrahim

- Caplan's syndrome.

Caplan's syndrome

*Def:-It is is a combination of rheumatoid arthritis and pneumoconiosis that manifests as intrapulmonary nodules.
*Synonyms:- rheumatoid pneumoconiosis.

*Causes:-

It occurs only in patient with both rheumatoid arthritis and pneumoconiosis related to mining dust (coal, asbestos, silica)so occurs in miners (especially those working in anthracite coal-mines), asbestosis, silicosis and other pneumoconioses.

- Felty's syndrome.

Felty's syndrome

*DeF:- It is a disorder characterized by the combination of rheumatoid arthritis, splenomegaly,neutropenia and repeated infections.
*It occurs in 5% of adult.

*Clinical picture:-

• Skin pigmentation and generalized lymphadenopathy.
• Splenomegaly.
• Hepatomegaly.
• Highly erosive and deforming arthiritis.
• L.E cells are +ve.
• Neutropenia so increase liability to certain infections.
• Fever, weight loss, and/or fatigue.