-Sjögren's syndrome.

Sjögren's syndrome

(Sicca syndrome.)

*Def:-

It is chronic inflammatory autoimmune disorder in which immune cells attack and destroy the exocrine glands(1)that produce tears and saliva.

*synonymes:-

• Mikulicz disease.
• Sicca syndrome.

*It is named after Swedish ophthalmologist Henrik Sjögren(2)(1899–1986) who first described it.

*Pathology:-

It is characterized by unusual infiltration of these glands that are responsible for fluid production by lymphocytes, thus causing decreased saliva (dry mouth), decreased tear production (dry eyes), and drying of other mucous membranes.

- Carpal tunnel syndrome.

Carpal tunnel syndrome 

*Def:- is a medical condition in which the median nerve is compressed inside the flexor retinaculum leading to paresthesias, numbness and muscle weakness in the hand.

*Causes:-

Due to fibrosis,fluid accumulation,soft tissue or bone hypertrophy which my be due to:-

"MEDIAN TRAP"(1)

Myxoedema
Edema
Diabetes mellitus,Drugs(e.g Oral contraceptive pills)
Idiopathic
Acromegaly
Neoplasm 

Trauma,Typists(Occuptional).
Rheumatoid arthritis
Amyloidosis
Pregnancy

-Brown-Séquard syndrome.

Brown-Séquard syndrome.
(Hemisection of spinal cord.)

*Aetiology:-
lesion in one side of the spinal cord as:-

• Stab wound.
• Disc prolapse.
• D.S.
• Tumor.
  
  

- Horner's syndrome.

Horner's syndrome

*Def:-

It is a clinical syndrome caused by damage to the sympathetic nerve supply to head and neck.

*synonymes:-

• Bernard-Horner syndrome
• oculosympathetic palsy.

*Causes:-

Due to lesion or compression of one side of the cervical or thoracic sympathetic chain which generates symptoms on the ipsilateral (same side as lesion) side of the body:-

-Toxic Causes of respiratory Failure.

Toxic Causes of respiratory Failure

1-Central:-

• Alcohol
• Barbiturate
• Opiate

2-Peripheral:-

A-Airway obstruction:-

• Falling back of the tongue.
• Vomitus.
• Excessive Secretions e.g Organophosphurus,carbamate.
• Oedema of the air way e.g Irritant fumes,Chlorine gas.
• Laryngeal spasm (Cyanide).
• Pneumonia(Hydrocarbon aspiration).
• Bronchospasm(Organophosphurus).
• Pulmonray
• oedema(Organo-phosphurus).

b-Paralysis of respiratory muscles:-

• Botulinum toxins.
• Snake bite.
• post-convulsion muscle exhaust.
• Organophosphurus.

C-Neuromuscular blocker:-

Physostigmine,Neostigmine.

Dr Ibrahim