Sertoli-cell-only syndrome (SCO)
-Def:- It is a condition in which only Sertoli cells line the seminiferous tubules of the testes and characterized by male sterility (due to azoospermia) without sexual abnormality.
- Synonyms:-
- Del Castillo syndrome.
- Germ cell aplasia.
- Most causes of SCO syndrome are idiopathic. A congenital absence of germ cells due to failure of migration of gonocytes is theoretically possible.
- Massive deletions in the azoospermia factor (AZF) region of the Y chromosome. found.
- Exposure to chemicals and toxins may cause SCO; however, direct cause-and-effect relationships in humans have been difficult to document.
- Klinefelter syndrome, 47 XXY, results in a characteristic biopsy appearance of SCO and Leydig cell hyperplasia.